SUBSTRATES

1A2

2B6

2C19

2C9

2D6

2E1

3A4,5,7

clozapine
cyclobenzaprine
imipramine
mexillitene
naproxen
riluzole
tacrine
theophylline

buproprion
cyclophosphamide
efavirenz
ifosfamide
methadone

Proton Pump Inhibitors:
omeprazole
lansoprazole
pantoprazole

Anti-epileptics:
diazepam
phenytoin
phenobarbitone
amitriptyline
clomipramine
cyclophosphamide

progesterone

NSAIDs:
diclofenac
ibuprofen
piroxicam

Oral Hypoglycemic Agents:
tolbutamide
glipizide


Angiotensin II Blockers:

NOT candesartan
irbesartan
losartan
NOT valsartan

celecoxib
fluvastatin naproxen
phenytoin
sulfamethoxazole
tamoxifen
tolbutamide
torsemide
warfarin

Beta Blockers:
S-metoprolol
propafenone
timolol


Antidepressants:

amitriptylline
clomipramine
desipramine
imipramine

paroxetine

Antipsychotics:

haloperidol
risperidone
thioridazine
codeine
dextromethorphan
flecainide
mexiletine
ondansetron
tamoxifen
tramadol
venlafaxine

acetaminophen
chlorzoxazone
ethanol

Macrolide antibiotics:
clarithromycin
erythromycin NOT azithromycin


Anti-arrhythmics:

quinidine

Benzodiazepines:
alprazolam
diazepam
midazolam
triazolam


Immune Modulators:

cyclosporine
tacrolimus (FK506)


HIV Protease Inhibitors:

indinavir
ritonavir
saquinavir


Prokinetic:

cisapride


Antihistamines:

astemizole
chlorpheniramine

Calcium Channel Blockers:
amlodipine
diltiazem
felodipine
nifedipine
nisoldipine
nitrendipine
verapamil

HMG CoA Reductase Inhibitors:
atorvastatin
cerivastatin
lovastatin
NOT pravastatin
simvastatin

buspirone
haloperidol (in part)
methadone
pimozide
quinine
NOT rosuvastatin
sildenafil
tamoxifen
trazodone
vincristine


INHIBITORS

1A2

2B6

2C19

2C9

2D6

2E1

3A4,5,7

cimetidine
fluoroquinolones
fluvoxamine
ticlopidine

thiotepa

fluoxetine
fluvoxamine
ketoconazole
lansoprazole
omeprazole
ticlopidine

amiodarone
fluconazole
isoniazid
ticlopidine

amiodarone
chlorpheniramine
cimetidine
clomipramine
fluoxetine
haloperidol
methadone
mibefradil
paroxetine
quinidine
ritonavir

disulfiram

HIV Protease Inhibitors:
indinavir
nelfinavir
ritonavir
saquinavir


amiodarone
NOT azithromycin
cimetidine
clarithromycin
diltiazem
erythromycin
fluoxetine
fluvoxamine
grapefruit juice
itraconazole
ketoconazole
mibefradil
nefazodone
troleandomycin
verapamil


INDUCERS

1A2

2B6

2C19

2C9

2D6

2E1

3A4,5,7

tobacco

phenobarbital rifampin

N/A

rifampin
secobarbital

N/A

ethanol
isoniazid

carbamazepine
phenobarbital
phenytoin
rifabutin
rifampin
St. John's wort
troglitazone